Acetyl chloride → HCID 22917845, compound

Participants

Reaction Steps

Acetylation of Compound 36 (0.6 g, 0.0016 mol) was performed with pyridine (0.8 mL) and acetyl chloride (0.8 mL) as described in the preparation of Compound 10. The crude product was chromatographed (silica gel; CH2Cl2 /acetone, 98:2) to provide 0.02 g colorless amorphous solid, mp 74°-75° C. The fractions eluted with CH2Cl2 /acetone (95:5) had both the acetate and the phenolic products, which were subjected to acetylation. Additional purification provided a total 0.1 g of Compound 37 (13.7%). 1H NMR (CDCl3) δ 2.26 (s, 6H, OCOCH3), 3.55 (s, 1H, ArCH), 6.96-7.66 (m, 13H, ArH).

Provenance & Evidence