Diphosgene → 2-Fluoro-4-(4-chlorophenylmethoxy)phenyl isocyanate

Participants

Reaction Conditions

Reaction Steps

A solution of 5.0 grams (0.02 mole) of 2-fluoro-4-(4-chlorophenylmethoxy)aniline in 150 mL of toluene was stirred and a solution of 3.4 mL (0.02 mole) of trichloromethyl chloroformate in 20 mL of toluene was added slowly. Upon completion of addition, the reaction mixture was stirred at 25° C. for one hour. After this time the reaction mixture was warmed to reflux, where it was stirred for about 18 hours. The reaction mixture was then concentrated under reduced pressure, yielding 5.5 grams of 2-fluoro-4-(4-chlorophenylmethoxy)phenyl isocyanate.

Provenance & Evidence