HCID 54323449, compound → Acetate

HRID 1609016Notes

Reaction equation

HRID 1609016 reaction equation
[C:1]([C:4]1[CH:27]=[CH:26][C:7]([C:8]([NH:10][CH2:11][CH2:12][C:13]2[CH:25]=[CH:24][C:16]([CH:17]([CH3:23])[CH2:18][C:19]([O:21][CH3:22])=[O:20])=[CH:15][CH:14]=2)=[O:9])=[CH:6][CH:5]=1)(=[NH:3])[NH2:2]>CO.[Pd]>[C:1]([C:4]1[CH:5]=[CH:6][C:7]([C:8]([NH:10][CH2:11][CH2:12][C:13]2[CH:14]=[CH:15][C:16](/[C:17](/[CH3:23])=[CH:18]/[C:19]([O:21][CH3:22])=[O:20])=[CH:24][CH:25]=2)=[O:9])=[CH:26][CH:27]=1)(=[NH:2])[NH2:3].[C:19]([O-:21])(=[O:20])[CH3:18]

Participants

5

Reactant 1

HCID 54323449HCID 54323449, compound

Product 2

HCID 175AcetateHCID 67854816HCID 67854816, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

190 mg of methyl (E)-p-[2-(p-amidinobenzamido)ethyl]-β-methylcinnamate were obtained after hydrogenation in methanol in the presence of 10% Pd/C under atmospheric pressure at room temperature after 24 hours 113 mg of crystalline acetate of methyl rac-p-[2-(p-amidinobenzamido) ethyl]-β-methyl-hydrocinnamate.

Sources & evidence

ORD record
ord-50391995cf5f4bc387a8496922e4d260
Source dataset
uspto-grants-1995_03
Patent number
US05399585

Reaction notes

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