HCID 54323449, compound → HCID 53822070, compound

HRID 1609017Notes

Reaction equation

HRID 1609017 reaction equation
[C:1]([C:4]1[CH:27]=[CH:26][C:7]([C:8]([NH:10][CH2:11][CH2:12][C:13]2[CH:25]=[CH:24][C:16]([CH:17]([CH3:23])[CH2:18][C:19]([O:21]C)=[O:20])=[CH:15][CH:14]=2)=[O:9])=[CH:6][CH:5]=1)(=[NH:3])[NH2:2]>CO>[C:1]([C:4]1[CH:5]=[CH:6][C:7]([C:8]([NH:10][CH2:11][CH2:12][C:13]2[CH:14]=[CH:15][C:16]([CH:17]([CH3:23])[CH2:18][C:19]([OH:21])=[O:20])=[CH:24][CH:25]=2)=[O:9])=[CH:26][CH:27]=1)(=[NH:2])[NH2:3]

Participants

3

Reactant 1

HCID 54323449HCID 54323449, compound

Product 1

HCID 53822070HCID 53822070, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

113 mg of methyl rac-p-[2-(p-amidinobenzamido)ethyl]-β-methylhydrocinnamate were dissolved in methanol/2 N sodium hydroxide solution and stored at room temperature overnight. The residue after removal of the solvent was dissolved in hot methanol, and ether was added. The crystals precipitated were filtered off with suction and dried over high vacuum, resulting in 52 mg of the sodium salt of rac-p-[2-(p-amidinobenzamido)ethyl]-β-methylhydrocinnamic acid. The melting point in dimethyl formamide was greater than 200° C.

Workup

  1. customThe residue after removal of the solvent
  2. dissolutionwas dissolved in hot methanol
  3. additionether was added
  4. customThe crystals precipitated
  5. filtrationwere filtered off with suction
  6. customdried over high vacuum

Sources & evidence

ORD record
ord-19024d86d8bc412bb4f15a3f7fe17b25
Source dataset
uspto-grants-1995_03
Patent number
US05399585

Reaction notes

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