Sodium Hydroxide → HCID 10356293, compound

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Reaction Steps

5.3 g (18 mmol) of methyl ester (6) obtained in Example 2 (1) was added to 250 ml of tetrahydrofuran, and, while the solution was heated under reflux, 100 ml of aqueous solution containing 0.76 g (19 mmol) of sodium hydroxide was added to the solution. The obtained solution was heated under reflux for 1.5 hours. After air-cooled, while cooling on ice, the solution was neutralized with 4.2 g (20 mmol) of citric hydrate and stirred for 1 hour. The solid was filtered off and washed consecutively with water, ethanol and ether to obtain 3.78 g of the subject compound (8) in a 75% yield. The result of the analysis of this compound was as follows.

Provenance & Evidence