p-Toluenesulfonic acid monohydrate → HCID 88402726, compound

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Reaction Steps

3.2 g of the compound (30) obtained in Example 5 (1) was dissolved in 110 ml of chloroform and 110 ml of methanol, and then 40 ml of methanol solution containing 6.37 g of p-toluenesufonic acid hydrate was added to the solution. The solution was stirred at room temperature for 40 minutes. The solvent was removed by distillation, and the crystal was dispersed in ethanol. The crystal was filtered off and washed successively with ethanol and ether to obtain 4.52 g of crude crystal. The crystal was recrystallized from a mixture solvent of ethanol and water to obtain 4.52 g of the subject compound (78). The result of the analysis of this compound was as follows.

Provenance & Evidence