4-t-Butylamino-3-fluoro-2-(2-hydroxyethyl)nitrobenzene → 4-Amino-3-fluoro-2-(2-hydroxyethyl)nitrobenzene

Participants

Reaction Steps

11 g of the compound (123) obtained in Comparative Example 5 was added to 200 ml of concentrated hydrochloric acid, and the solution heated at reflux for 2.5 hours. After air-cooling, the solution was extracted with 500 ml of ethyl acetate four times, and the extract was washed with aqueous 10% sodium hydrogen carbonate solution. After drying over magnesium sulfate, the solvent was removed by distillation. The residue was crystallized with n-hexane, and the crystals were filtered to obtain 8.33 g of the subject compound (124) in a 97% yield.

Provenance & Evidence