Hydrochloric Acid → 2,3-Difluoro-α-methyl-6-nitrobenzeneethanol

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Reaction Steps

31.2 g (145 mmol) of the compound (148) obtained above was added to 500 ml of methanol, and while cooling on ice, 6.04 g (160 mmol) of sodium borohydride was added to the solution through 5 minutes. After the solution was stirred for 30 minutes as was, the solution was stirred overnight at room temperature. 100 ml of 4N hydrochloric acid was added slowly to the solution and the solution was stirred for 30 minutes at room temperature. Then, the solvent was removed by distillation. The solution was extracted with 400 ml of chloroform, and after drying over magnesium sulfate, the solvent was removed by distillation to obtain 27.7 g of the subject compound (149) in a 89% yield.

Provenance & Evidence