Formaldehyde → HCID 20083158, compound

HRID 1609089Notes

Reaction equation

HRID 1609089 reaction equation
[F:1][C:2]1[C:11]([F:12])=[CH:10][C:9]2[C:13](=[O:21])[C:14]([C:16]([O:18][CH2:19][CH3:20])=[O:17])=[CH:15][N:7]3[C:8]=2[C:3]=1[CH2:4][CH2:5][NH:6]3.[CH2:22]=[O:23]>C(O)(=O)C>[F:1][C:2]1[C:11]([F:12])=[CH:10][C:9]2[C:13](=[O:21])[C:14]([C:16]([O:18][CH2:19][CH3:20])=[O:17])=[CH:15][N:7]3[C:8]=2[C:3]=1[CH2:4][CH2:5][N:6]3[CH2:22][OH:23]

Participants

4

Reactant 2

HCID 712FormaldehydeHCID 20083163HCID 20083163, compound

Product 1

HCID 20083158HCID 20083158, compound

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

100 mg of the compound (5) obtained in Example 1 was dissolved in 3 ml of acetic acid, and while stirring, 1.5 ml of formalin was added to the solution. The solution was stirred for 30 minutes, and the deposited solid matter was filtered off and washed with ether to obtain 64 mg of the subject compound (177).

Workup

  1. stirringThe solution was stirred for 30 minutes
  2. filtrationthe deposited solid matter was filtered off
  3. washwashed with ether

Sources & evidence

ORD record
ord-cade7254eef9434d815b4b4a64103987
Source dataset
uspto-grants-1995_03
Patent number
US05399553

Reaction notes

Loading…