Formaldehyde → HCID 20083117, compound

HRID 1609090Notes

Reaction equation

HRID 1609090 reaction equation
[F:1][C:2]1[C:3]([N:21]2[CH2:25][CH2:24][CH2:23][CH2:22]2)=[C:4]2[C:9]3=[C:10]([C:12](=[O:18])[C:13]([C:15]([OH:17])=[O:16])=[CH:14][N:8]3[N:7]([CH3:19])[CH:6](C)[CH2:5]2)[CH:11]=1.C=[O:27]>C(O)(=O)C>[F:1][C:2]1[C:3]([N:21]2[CH2:25][CH2:24][CH2:23][CH2:22]2)=[C:4]2[C:9]3=[C:10]([C:12](=[O:18])[C:13]([C:15]([OH:17])=[O:16])=[CH:14][N:8]3[N:7]([CH2:19][OH:27])[CH2:6][CH2:5]2)[CH:11]=1

Participants

4

Reactant 2

HCID 712FormaldehydeHCID 20083094HCID 20083094, compound

Product 1

HCID 20083117HCID 20083117, compound

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Conditions

Temperature
80 °C

Procedure

200 mg of the compound (160) obtained in Example 38 was added to a mixture solvent of 8 ml of acetic acid and 4 ml of formalin, and the solution was heated at 80° C. for 2 hours. The deposited solid matter was filtered off and washed with ether to obtain 50 mg of the subject compound (179).

Workup

  1. filtrationThe deposited solid matter was filtered off
  2. washwashed with ether

Sources & evidence

ORD record
ord-ef90edff7f3c4880be2f974e48b1091d
Source dataset
uspto-grants-1995_03
Patent number
US05399553

Reaction notes

Loading…