Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Acetic Acid | HCID 176 | — |
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | HCID 20083100 | HCID 20083100 | — |
| Solvent | Water | HCID 962 | — |
| Product | HCID 20083140 | HCID 20083140 | 81% |
Reaction Steps
30 mg of the compound (198) obtained in Example 69 was added to 0.4 ml of acetic acid and 0.1 ml of 12N hydrochloric acid, and the solution was heated at 100° C. for 2 hours. After air-cooling, water was added to the reaction solution, and deposited solids were filtered off and washed with water, ethanol and ether in this order to obtain 22 mg of the subject compound (199) in a 81% yield.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US05399553 |
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| Source dataset | uspto-grants-1995_03 |
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| ORD ID | ord-b147283723564179b355e0231a03bffe |
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| Source note | uspto-grants-1995_03 |
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