Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Toluene | HCID 1140 | — |
| Reactant | Chloroform | HCID 6212 | — |
| Reactant | Benzylamine | HCID 7504 | — |
| Reactant | HCID 20083100 | HCID 20083100 | — |
| Solvent | Diethyl Ether | HCID 3283 | — |
| Product | HCID 20083185 | HCID 20083185 | 75.6% |
Reaction Steps
62 mg of the compound (198) obtained in Example 69 and 50 mg of benzylamine were added to 2 ml of toluene, and the solution was heated at 80° C. for 24 hours. The reaction solution was added to chloroform and was washed with aqueous 5% citric acid solution. After drying over magnesium sulfate, the solvent was removed by distillation. Obtained solids were dispersed in ether and filtered off to obtain 59 mg of the subject compound (200) in a 74% yield.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US05399553 |
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| Source dataset | uspto-grants-1995_03 |
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| ORD ID | ord-5c4461b09e8e4be7b202be0635b8b427 |
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| Source note | uspto-grants-1995_03 |
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