HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → Ammonia
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | Valeryl chloride | HCID 61186 | — |
| Reactant | HCID 178504271 | HCID 178504271 | — |
| Solvent | Dichloromethane methanol | HCID 21226129 | — |
| Product | Ammonia | HCID 222 | — |
| Product | HCID 178447308 | HCID 178447308 | — |
Reaction Steps
Reaction of 0.45 g of N-[(2'-(trimethylsilylethoxycarbonyl)biphenyl-4-yl)methyl]3-(imidazol-4-yl)-2-(S)-aminopropan-1-ol, 0.152 ml of triethylamine and 0.132 ml of valeryl chloride yields N-[3-(imidazol-4-yl)-1-hydroxy-2-propyl]-N-[(2'-(trimethylsilylethoxycarbonyl)biphenyl-4-yl)methyl]valeramide after flash chromatography (methylene chloride-methanol-conc. ammonia: 120-10-1). During working up, the aqueous phase is rendered slightly basic. FAB-MS: m/e=536 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05399578 |
| Source dataset | uspto-grants-1995_03 |
| ORD ID | ord-89d59d7dfb83403c94d8aea87008380e |
| Source note | uspto-grants-1995_03 |