4'-Formyl-[1,1'-biphenyl]-2-carbonitrile → HCID 66577501, compound

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Reaction Steps

The starting material can be obtained, for example, analogously to Example 1b): Reaction of 2.0 g of 2'-cyanobiphenyl-4-carbaldehyde, 9.6 g of molecular sieve 5 A, 1.34 g of (D)-alanine methyl ester hydrochloride and 680 mg of sodium cyanoborohydride yields N-[(2'-cyanobiphenyl-4-yl)methyl]-(D)-alanine methyl ester after flash chromatography (N3). 1H-NMR (DMSO): 1.21 ppm (d, 3H), 3.63 ppm (s, 3H), 3.75 ppm (dd, 1H), 4.56 ppm (d, 2H), 4.58 ppm (d, 2H), 5.31 ppm (t, 1H), 7.4-8 ppm aromatics.

Provenance & Evidence