HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methyl valinate hydrochloride → N-((2'-Cyano(1,1'-biphenyl)-4-yl)methyl)-L-valine methyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methyl valinate hydrochloride | HCID 111190 | — |
| Reactant | 4'-Formyl-[1,1'-biphenyl]-2-carbonitrile | HCID 1394062 | — |
| Reactant | Sodium cyanoborohydride | HCID 5003444 | — |
| Product | N-((2'-Cyano(1,1'-biphenyl)-4-yl)methyl)-L-valine methyl ester | HCID 16744794 | — |
Reaction Steps
The starting material can be obtained, for example, analogously to Example 1b): Reaction of 0.5 g of 2'-cyanobiphenyl-4-carbaldehyde, 2.5 g of molecular sieve 5 A, 0.815 g of (L)-valine methyl ester hydrochloride and 180 mg of sodium cyanoborohydride yields N-[(2'-cyanobiphenyl-4-yl)methyl]-(L)-valine methyl ester after flash chromatography (N3). (TLC: N3) Rf : 0.5.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05399578 |
| Source dataset | uspto-grants-1995_03 |
| ORD ID | ord-b20ea53950684f5ab80f396ac16bec08 |
| Source note | uspto-grants-1995_03 |