HuagongsheHuagongshe Chemistry Print Report · For research reference only
4'-Formyl-[1,1'-biphenyl]-2-carbonitrile → N-[(2′-Cyano[1,1′-biphenyl]-4-yl)methyl]-D-valine methyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4'-Formyl-[1,1'-biphenyl]-2-carbonitrile | HCID 1394062 | — |
| Reactant | Sodium cyanoborohydride | HCID 5003444 | — |
| Reactant | Methyl D-valinate hydrochloride | HCID 11984198 | — |
| Product | N-[(2′-Cyano[1,1′-biphenyl]-4-yl)methyl]-D-valine methyl ester | HCID 29924795 | — |
Reaction Steps
The starting material can be obtained, for example, analogously to Example 1b): Reaction of 4.0 g of 2'-cyanobiphenyl-4-carbaldehyde, 19.3 g of molecular sieve 5 A, 3.8 g of (D)-valine methyl ester hydrochloride and 1.43 g of sodium cyanoborohydride yields N-[(2'-cyanobiphenyl-4-yl)methyl]-(D)-valine methyl ester after flash chromatography (N3). (TLC: N2) Rf : 0.56.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05399578 |
| Source dataset | uspto-grants-1995_03 |
| ORD ID | ord-fd61749edd6844a1a949cc3983853acb |
| Source note | uspto-grants-1995_03 |