HCID 178447290, compound → HCID 178447289, compound

HRID 1609190Notes

Reaction equation

HRID 1609190 reaction equation
[NH:1]1[C:5]([C:6]2[CH:11]=[CH:10][CH:9]=[CH:8][C:7]=2[C:12]2[CH:17]=[CH:16][C:15]([CH2:18][N:19]([CH2:26][CH:27]([CH:33]([CH3:35])[CH3:34])[C:28]([O:30]CC)=[O:29])[C:20](=[O:25])[CH2:21][CH2:22][CH2:23][CH3:24])=[CH:14][CH:13]=2)=[N:4][N:3]=[N:2]1>[OH-].[Na+]>[C:28]([CH:27]([CH:33]([CH3:34])[CH3:35])[CH2:26][N:19]([C:20](=[O:25])[CH2:21][CH2:22][CH2:23][CH3:24])[CH2:18][C:15]1[CH:14]=[CH:13][C:12]([C:7]2[CH:8]=[CH:9][CH:10]=[CH:11][C:6]=2[C:5]2[NH:4][N:3]=[N:2][N:1]=2)=[CH:17][CH:16]=1)([OH:30])=[O:29]

Participants

3

Reactant 1

HCID 178447290HCID 178447290, compound

Product 1

HCID 178447289HCID 178447289, compound

Reagents, catalysts & solvents 1

HCID 14798Sodium HydroxideSolvent

Procedure

980 mg of ethyl rac-N-[(2'-(1H-tetrazol-5-yl)biphenyl-4-yl)methyl]-N-valeryl-2-(aminomethyl)-3-methylbutanoate in 3.1 ml of 2N NaOH are heated at 100° for 72 hours. Neutralization with 3.1 ml of 2N HCl and extraction with CH2Cl2 yields the product, Rf =0.30 (system N8).

Workup

  1. extractionNeutralization with 3.1 ml of 2N HCl and extraction with CH2Cl2
  2. customyields the product, Rf =0.30 (system N8)

Sources & evidence

ORD record
ord-97a7ed87304940d5a2bce2bb82869f6d
Source dataset
uspto-grants-1995_03
Patent number
US05399578

Reaction notes

Loading…