HuagongsheHuagongshe Chemistry Print Report · For research reference only
Valeryl chloride → Benzyl(S)-2-((2'-cyanobiphenyl-4-ylmethyl)pentanoylamino)-3-methylbutyrate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Valeryl chloride | HCID 61186 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | (2S)-2-(2'-Cyano-4-biphenylylmethylamino)-3-methylbutyric acid benzyl ester | HCID 11112111 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | Benzyl(S)-2-((2'-cyanobiphenyl-4-ylmethyl)pentanoylamino)-3-methylbutyrate | HCID 46912012 | — |
Reaction Steps
6.2 g (15.5 mmol) of N-[(2'-cyanobiphenyl-4-yl)methyl]-(L)-valine benzyl ester and 8.0 ml of Hunig base, dissolved in 50 ml of methylene chloride, are treated with 2.3 ml of valeryl chloride with stirring and further processed analogously to Example 29b. The title compound is thus obtained as a yellow oil which is further used in crude form (Rf 0.51, toluene-methanol 19:1)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05399578 |
| Source dataset | uspto-grants-1995_03 |
| ORD ID | ord-1ab919209ed046bf946fd12c3ce6b49f |
| Source note | uspto-grants-1995_03 |