Tributyltin azide → HCID 178447276, compound

Participants

Reaction Steps

A solution of 4.5 g (8 mmol) of N-[(3-bromo-2'-cyanobiphenyl-4-yl)methyl]-N-valeryl-(L)-valine benzyl ester and 3.4 g (10.4 mmol) of tributyltin azide in 50 ml of xylene is heated to boiling under reflux for 20 hours. Working-up analogously to Example 54 and "flash"-chromatographic purification (toluene-methanol 4:1 ) gives the title compound as a colourless foam (Rf 0.57, system A2).

Provenance & Evidence