反应详情

5.6 g (0.035 mmol) of bromine, dissolved in 20 ml of tetrachloroethane, are added dropwise at 100°-110° with UV irradiation to a solution of 8.9 g (0.033 mol) of 3'-bromo-4' -methyl-1,1'-biphenyl-2-carbonitrile in 900 ml of tetrachloroethane after addition of 0.1 g of benzoyl peroxide. After 30 minutes, the reaction mixture is cooled and evaporated in vacuo. The crystalline residue is recrystallized from ethyl acetate and gives 4.1 g of the title compound of m.p. 152°-153°.

1. temperaturethe reaction mixture is cooled
2. customevaporated in vacuo
3. customThe crystalline residue is recrystallized from ethyl acetate