HCID 178447297, compound → HCID 178447296, compound

Participants

Reaction Steps

170 mg of (S)-N-(1-benzyloxycarbonyl-5-benzyloxycarbonylamino-pent-1-yl)-N-pentanoyl-N-[2 '-(1H-tetrazol-5-yl)biphenyl-4-ylmethyl]-amine are dissolved in 5 ml of methanol. The solution is treated with 170 mg of palladium/carbon (10%) and the mixture is hydrogenated to saturation under normal pressure and at room temperature. The mixture is filtered over Hyflo and the filtrate is evaporated, yielding the pure (S)-N-(5-amino-1-carboxy-pent-1-yl)-N-pentanoyl-N-[2'-(1H-tetrazol-5-yl)biphenyl-4-ylmethyl]-amine in the form of a white foam [MS (FAB): m/z=465, (M+H)+ ].

Provenance & Evidence