Hydrochloric Acid → HCID 178447297, compound

Participants

Reaction Steps

1.07 g of (S)-N-(1-benzyloxycarbonyl-5-benzyloxycarbonylamino-pent-1-yl)-N-pentanoyl-N-[2'-(1-triphenylmethyl-1H-tetrazol-5-yl)biphenyl-4-ylmethyl]-amine are dissolved in 15 ml of dioxane. This solution is treated with 1.5 ml of a solution of hydrogen chloride in dioxane (7 N), the mixture is stirred for 4.5 hours at 40° and then evaporated, and the residue is purified by means of flash-chromatography (200 g of silica gel; system N6). The (S)-N-(1-benzyloxycarbonyl-5-benzyloxycarbonylamino-pent-1-yl)-N-pentanoyl-N-[2'-(1H-tetrazol-5-yl)biphenyl-4-ylmethyl]-amine [Rf : 0.42 (system N7)] is thus obtained.

Provenance & Evidence