Hydrochloric Acid → HCID 178455632, compound

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Reaction Steps

750 mg of (S)-N-butanesulfonyl-N-(1-tert.-butoxycarbonylethyl)-N-[2'-(1H-tetrazol-5-yl)biphenyl-4-ylmethyl]-amine are treated for 24 hours at 0° with a solution of hydrogen chloride in glacial acetic acid (1.9N). Evaporation of the mixture and flash-chromatography of the residue (100 g of silica gel; CH2Cl2 /ethyl acetate/toluene/formic acid=40:40:20:4) yields the (S)-N-butanesulfonyl-N-(1-carboxyethyl)-N-[2'-(1H-tetrazol-5-yl)biphenyl-4-ylmethyl]-amine in the form of a white amorphous powder [m.p.: 90° (decomposition at 127°)].

Provenance & Evidence