2-Mercaptobenzoic Acid → HCID 11197435, compound

Participants

Reaction Conditions

Reaction Steps

In 100 ml of N,N-dimethylformamide was dissolved 15.4 g of thiosalicylic acid followed by addition of 42 g of potassium carbonate and 14.8 g of 2-fluoronitrobenzene, and the mixture was stirred at 100° C. for 3 hours. After the reaction mixture had cooled to room temperature, 18.7 g of ethyl iodide was added thereto and the mixture was further stirred at room temperature for 3 hours. The reaction mixture was then poured into ice-water and extracted with ether. The ether layer was washed with water twice, dried and concentrated. Finally the residue was crystallized from ethanol to give 25.5 g of the title compound as yellow crystals.

Provenance & Evidence