Ammonia → HCID 20084454, compound

HRID 1609273Notes

Reaction equation

HRID 1609273 reaction equation
[CH2:1]([O:8][C:9]1[CH:33]=[CH:32][C:12]([C:13]([NH:15][C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][C:17]=2[S:22][C:23]2[CH:31]=[CH:30][CH:29]=[CH:28][C:24]=2[C:25](O)=[O:26])=[O:14])=[CH:11][CH:10]=1)/[CH:2]=[CH:3]/[CH2:4][CH2:5][CH2:6][CH3:7].[NH3:34]>C1C=CC=CC=1>[CH2:1]([O:8][C:9]1[CH:33]=[CH:32][C:12]([C:13]([NH:15][C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][C:17]=2[S:22][C:23]2[CH:31]=[CH:30][CH:29]=[CH:28][C:24]=2[C:25]([NH2:34])=[O:26])=[O:14])=[CH:11][CH:10]=1)/[CH:2]=[CH:3]/[CH2:4][CH2:5][CH2:6][CH3:7]

Participants

4

Reactant 2

HCID 222AmmoniaHCID 20084545HCID 20084545, compound

Product 1

HCID 20084454HCID 20084454, compound

Reagents, catalysts & solvents 1

HCID 241BenzeneSolvent

Procedure

In 40 ml of benzene was suspended 2.8 g of (E)-2-[2-[4-(2-heptenyloxy)benzoylamino]phenylthio]benzoic acid followed by addition of 1.2 g of N,N'-carbonyldiimidazole, and the mixture was stirred at room temperature for 2 hours. Ammonia gas was introduced into the mixture with ice-cooling and stirring for 20 minutes and the mixture was then allowed to stand at room temperature for 2 hours. The crystals separated out therefrom were collected by filtration and washed with ethyl acetate to give 2.6 g of the title compound as white crystals.

Workup

  1. temperaturecooling
  2. stirringstirring for 20 minutes
  3. waitto stand at room temperature for 2 hours
  4. customThe crystals separated out
  5. filtrationtherefrom were collected by filtration
  6. washwashed with ethyl acetate

Sources & evidence

ORD record
ord-35695d13901a4d429a36a3a3827750b4
Source dataset
uspto-grants-1995_03
Patent number
US05399703

Reaction notes

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