Sodium Hydroxide → HCID 178525962, compound

HRID 1609294Notes

Reaction equation

HRID 1609294 reaction equation
[NH:1]1[C:5]([C:6]2[CH:11]=[CH:10][CH:9]=[CH:8][C:7]=2[S:12][C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=2[NH:19][C:20]([C:22]2[CH:33]=[CH:32][C:25]([O:26][CH2:27][C:28]([O:30]C)=[O:29])=[CH:24][CH:23]=2)=[O:21])=[N:4][N:3]=[N:2]1.[OH-].[Na+]>C(O)C>[NH:4]1[C:5]([C:6]2[CH:11]=[CH:10][CH:9]=[CH:8][C:7]=2[S:12][C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=2[NH:19][C:20]([C:22]2[CH:23]=[CH:24][C:25]([O:26][CH2:27][C:28]([OH:30])=[O:29])=[CH:32][CH:33]=2)=[O:21])=[N:1][N:2]=[N:3]1

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 178501778HCID 178501778, compound

Product 1

HCID 178525962HCID 178525962, compoundYield 86.9%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

In 10 ml of ethanol was suspended 0.38 g of methyl 4-[2-[2-(1H-tetrazol-5-yl)phenylthio]phenylcarbamoyl]-p-henoxyacetate followed by addition of 1 ml of 10% sodium hydroxide, and the mixture was heated on a water bath for 10 minutes. After cooling, the reaction mixture was acidified with concentrated hydrochloic acid and diluted with water. The precipitate was collected by filtration and washed with water, ethanol and ethyl acetate in the order mentioned to give 0.32 g of the title compound as white crystals, m.p. 252°-253° C.

Workup

  1. temperaturethe mixture was heated on a water bath for 10 minutes
  2. temperatureAfter cooling
  3. concentrationwith concentrated hydrochloic acid
  4. additiondiluted with water
  5. filtrationThe precipitate was collected by filtration
  6. washwashed with water, ethanol and ethyl acetate in the order

Sources & evidence

ORD record
ord-ee76f426cb7d4a69975a6e378aa14795
Source dataset
uspto-grants-1995_03
Patent number
US05399703

Reaction notes

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