反应详情

In 10 ml of ethanol was suspended 0.38 g of methyl 4-[2-[2-(1H-tetrazol-5-yl)phenylthio]phenylcarbamoyl]-p-henoxyacetate followed by addition of 1 ml of 10% sodium hydroxide, and the mixture was heated on a water bath for 10 minutes. After cooling, the reaction mixture was acidified with concentrated hydrochloic acid and diluted with water. The precipitate was collected by filtration and washed with water, ethanol and ethyl acetate in the order mentioned to give 0.32 g of the title compound as white crystals, m.p. 252°-253° C.

1. temperaturethe mixture was heated on a water bath for 10 minutes
2. temperatureAfter cooling
3. concentrationwith concentrated hydrochloic acid
4. additiondiluted with water
5. filtrationThe precipitate was collected by filtration
6. washwashed with water, ethanol and ethyl acetate in the order