Hydrochloric Acid → HCID 178514045, compound

Participants

Reaction Steps

In 6 ml of N,N-dimethylformamide was dissolved 0.63 g of 4-[2-[2-(1H-tetrazol-5-yl)phenylthio]phenylcarbamoyl]phenoxyacetic acid (prepared in Example 6) followed by addition of 0.24 g of N,N'-carbonyldiimidazole. The mixture was stirred at room temperature for 1 hour, and then it was poured in 28% aqueous ammonia and stirred for 1 hour. The reaction mixture was diluted with water and, then, acidified with concentrated hydrochloric acid, and the crystals separated out therefrom were collected by filtration and washed with water. The crude crystals thus obtained were recrystallized from N,N-dimethyl-formamide-ethanol to give 0.52 g of the title compound as white crystals.

Provenance & Evidence