HuagongsheHuagongshe Chemistry Print Report · For research reference only
Toluene → (E)-5-methoxy-2-[2-[3-[2-[4-(cyclobutyl)-2-thiazolyl]ethenyl]phenylamino]-2-oxoethyl]benzoic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Toluene | HCID 1140 | — |
| Reactant | Tetrahydrofuran | HCID 8028 | — |
| Reactant | 5-Methoxyhomophthalic anhydride | HCID 11019674 | — |
| Reactant | (E)-3-[2-[4-(cyclobutyl)-2-thiazolyl]ethenyl]benzeneamine | HCID 15136086 | — |
| Product | (E)-5-methoxy-2-[2-[3-[2-[4-(cyclobutyl)-2-thiazolyl]ethenyl]phenylamino]-2-oxoethyl]benzoic acid | HCID 20084319 | — |
Reaction Steps
A solution of 0.4 g of (E)-3-[2-[4-(cyclobutyl)-2-thiazolyl]ethenyl]benzeneamine, 0.4 g of 5-methoxyhomophthalic anhydride, 50 ml of toluene and 10 ml of tetrahydrofuran was heated to reflux for 0.5 hr. The solvents were removed by rotary evaporation and the residual materials were triturated with ethanol to yield (E)-5-methoxy-2-[2-[3-[2-[4-(cyclobutyl)-2-thiazolyl]ethenyl]phenylamino]-2-oxoethyl]benzoic acid, m.p. 190°-191° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05399702 |
| Source dataset | uspto-grants-1995_03 |
| ORD ID | ord-bc6466854cf84088bfb72420786eb254 |
| Source note | uspto-grants-1995_03 |