HuagongsheHuagongshe Chemistry Print Report · For research reference only
5-Acetoxyhomophthalic anhydride → (E)-5-acetoxy-2-[2-[3-[2-[4-(cyclobutyl)-2-thiazolyl]ethenyl]phenylamino]-2-oxoethyl]benzoic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 5-Acetoxyhomophthalic anhydride | HCID 12436397 | — |
| Reactant | (E)-3-[2-[4-(cyclobutyl)-2-thiazolyl]ethenyl]benzeneamine | HCID 15136086 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | (E)-5-acetoxy-2-[2-[3-[2-[4-(cyclobutyl)-2-thiazolyl]ethenyl]phenylamino]-2-oxoethyl]benzoic acid | HCID 20084344 | 148.2% |
Reaction Steps
A mixture composed of 0.58g of (E)-3-[2-[4-(cyclobutyl)-2-thiazolyl]ethenyl]benzeneamine, 0.48g of 5-acetoxyhomophthalic anhydride and 50 ml of toluene was heated on a steam bath for 0.5 hr. The mixture was cooled and the solids that formed were isolated by filtration to yield 0.77 g of (E)-5-acetoxy-2-[2-[3-[2-[4-(cyclobutyl)-2-thiazolyl]ethenyl]phenylamino]-2-oxoethyl]benzoic acid; m.p. 176°-179° C. after trituration with hot acetonitrile.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05399702 |
| Source dataset | uspto-grants-1995_03 |
| ORD ID | ord-e7d4afd234e04862b3ce4b00d414ffc8 |
| Source note | uspto-grants-1995_03 |