HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetic Anhydride → Diisopropylethylamine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetic Anhydride | HCID 7918 | — |
| Reactant | Tetrahydrofuran | HCID 8028 | — |
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | Propionic anhydride | HCID 31263 | — |
| Solvent | Toluene | HCID 1140 | — |
| Solvent | 1,2-Dimethoxyethane | HCID 8071 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | Diisopropylethylamine | HCID 81531 | — |
Reaction Steps
The amide acid VIIC is cyclized by treatment with a cyclizing agent such as acetic anhydride or propionic anhydride (employing a molar ratio of anhydride:VIIC of within the range of from about 7:1 to about 5:1) and amine base such as triethylamine or diisopropylethylamine, in the presence of an inert organic solvent such as THF, toluene, monoglyme or ethylacetate, at a temperature within the range of from about 70° to about 110° C., to form compound XXVIII.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05399725 |
| Source dataset | uspto-grants-1995_03 |
| ORD ID | ord-bf5f076b8dda4432bf12d49a91eb4e60 |
| Source note | uspto-grants-1995_03 |