Ammonia → HCID 20085028, compound

Participants

Reaction Steps

About 2208 g (48 moles) of anhydrous ethanol was added to the reaction mixture containing the N-chloromethyl-α-chloroacetanilide intermediate. The addition of ethanol to the haloacetanilide mixture was done over 40 minutes at temperatures ranging from 45°-84° C. At the end of the ethanol addition, about 66.3 g (3.9 moles) of gaseous ammonia was introduced to the reaction mixture through a dip tube at about 50°-60° C. When the pH of the reaction mixture was about 8-9, the addition of ammonia was stopped and the reaction was considered complete. This reaction gave a 98.6% conversion of the haloacetanilide intermediate to the N-ethoxymethyl-2-chloroacetanilide.

Provenance & Evidence