HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → Isopropyl 1-methyl-3-indoleacetimidate hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Isopropanol | HCID 3776 | — |
| Reactant | 2-(1-methyl-1H-indol-3-yl)acetonitrile | HCID 10654720 | — |
| Product | Isopropyl 1-methyl-3-indoleacetimidate hydrochloride | HCID 22907276 | 44% |
Reaction Steps
Hydrogen chloride was bubbled through a stirred solution of 7.5 g (44 mmol) of 1-methylindole-3-acetonitrile in 100ml of dry isopropanol at room temperature. After 4 hours, the solvent was removed under reduced pressure and the residue was triturated with diethyl ether to give 5.17 g (44%) of isopropyl 1-methyl-3-indoleacetimidate hydrochloride as a white solid of melting point 133° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05399712 |
| Source dataset | uspto-grants-1995_03 |
| ORD ID | ord-968189737b3e40409f7af5ed50844dcc |
| Source note | uspto-grants-1995_03 |