HuagongsheHuagongshe Chemistry Print Report · For research reference only
Anthranilic Acid → N-Phenylanthranilic Acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Anthranilic Acid | HCID 227 | — |
| Reactant | 2-Bromo-4-methyl-1-nitrobenzene | HCID 8167038 | — |
| Product | N-Phenylanthranilic Acid | HCID 4386 | — |
Reaction Steps
As shown in Scheme 7, coupling of 3-bromo-4-nitrotoluene with 2-amino-benzoic acid via an Ullmann reaction yields an N-phenyl-anthranilic acid. After protection of the acid with 2-amino-2-methyl-1-propanol, oxidation affords the corresponding aldehyde. Addition of vinyl magnesium bromide and deprotection provides the N-phenyl-anthranilic acid containing a latent Michael acceptor. ##STR15##
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05399790 |
| Source dataset | uspto-grants-1995_03 |
| ORD ID | ord-920e207501f64dc5941e0fe889c060c3 |
| Source note | uspto-grants-1995_03 |