Water → HCID 20081440, compound

Participants

Reaction Steps

Potassium tert-butoxide (1.4 g) was added with stirring and cooling to the product of Example 1 (4.0 g) in dimethylformamide (25 ml). Iodomethane (1.78 g) was added portionwise, stirring was continued for 2 hours and the reaction mixture was allowed to stand at room temperature for 8 days. Addition to water and isolation through ethyl acetate gave the crude title product as a yellow oil. Purification by flash chromatography on silica gel in 10% ethyl acetate/dichloromethane gave 2.3 g (55%) pure product as a pale yellow oil.

Provenance & Evidence