2,6-Di-tert-butyl-4-methylphenol → HCID 15239537, compound

Participants

Reaction Steps

In a 100 ml flask equipped with a thermometer, a cooling tube and a nitrogen-introducing tube, there were charged 2-trimethylsilylethyl 2-[(4,6-dimethoxypyrimidin-2-yl)oxy]-6-trifluoromethylsulfonyloxybenzoate (3.15 g, 6.0 mmol), tetrakis(triphenylphosphine)palladium(0) (400 mg, 0.34 mmol) and toluene (30 ml), and the resultant mixture was stirred at room temperature for 1 hour under nitrogen stream. After adding 2,6-di-tert-butyl-4-methylphenol (catalytic amount) to the resultant mixture, vinyl tributyl tin (3.17 g, 10.0 mmol) was further added and the mixture was reacted at 80°-90° C. for 3 hours. After cooling the mixture, toluene was added thereto and the organic layer was washed with water and a saturated salt water, dried with anhydrous sodium sulfate and concentrated. The residue thus obtained was purified by silica gel column chromatography to obtain 0.50 g (yield: 20.8%) of the aimed product (transparent viscous orange color liquid).

Provenance & Evidence