Hydrazine → 2-Buten-1-amine, 4-[3-(1-piperidinylmethyl)phenoxy]-, (E)-

関与物質

反応手順

In the same manner as in Example 1, the N-[4-chloro(trans) 2-butenyl]phthalimide was reacted with 3-(1-piperidinomethyl)phenol, followed by hydrolysis with hydrazine to obtain 1.56 g of 4-[3-(1-piperidinomethyl)phenoxy]-(trans) 2-butenylamine. To a solution of 1 g of this amine compound in 30 ml of chloroform was added 0.9 g of the 3-chloro-4-methyl-1,2,4-benzothiadiazine-1,1-dioxide, followed by the same treatment as in Example 1 to obtain 1.57 g of white crystalline 3-[N-[4-[3-(1-piperidinomethyl)phenoxy]-(trans) 2-butenyl]amino]-4-methyl-1,2,4-benzothiadiazine-1,1-dioxide (compound 23, yield 90% ). M.p. 116°~120° C.

情報源と証拠