Hydrochloric Acid → 3-(3-methyl-4-nitrophenyl)methyl-L-histidine dihydrochloride

Participants

Reaction Conditions

Reaction Steps

A 6N hydrochloric acid solution (54.5 ml) was added to 3-(3-methyl-4-nitrophenyl)methyl-N-t-butoxycarbonyl-L-histidine methyl ester (IX-2) (1.3626 g, 0.00326 mol), and the mixture was refluxed under heating on a 120° C. oil bath for 2.5 hours. The resulting solution was cooled and then concentrated to obtain the objective compound (VIII-2) (1.1406 g; yield: 92.9%) as a light-brown oily material.

Provenance & Evidence