HCID 19387898, compound → HCID 20081971, compound

HRID 1609514Notes

Reaction equation

HRID 1609514 reaction equation
Br.[N:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8]#[C:9][CH2:10]Br.[OH:12][C:13]1[CH:14]=[C:15]([C:19]2([O:25][CH3:26])[CH2:23][CH2:22][O:21][CH:20]2[CH3:24])[CH:16]=[CH:17][CH:18]=1>>[CH3:26][O:25][C:19]1([C:15]2[CH:16]=[CH:17][CH:18]=[C:13]([O:12][CH2:10][C:9]#[C:8][C:3]3[CH:4]=[CH:5][CH:6]=[CH:7][N:2]=3)[CH:14]=2)[CH2:23][CH2:22][O:21][CH:20]1[CH3:24]

Participants

3

Reactant 2

HCID 19387898HCID 19387898, compoundHCID 67797113HCID 67797113, compound

Product 1

HCID 20081971HCID 20081971, compoundYield 90%

Procedure

Using the procedure described in Example 1, 3-(2-pyridyl)prop-2-yn-1-yl bromide hydrobromide was reacted with (2RS,3SR)-3-(3-hydroxyphenyl)-3-methoxy-2-methyltetrahydrofuran to give (2RS,3SR)-3-methoxy-2-methyl-3-[3-(3-(2-pyridyl)prop-2-yn-1-yloxy)phenyl]tetrahydrofuran, as an oil in 90% yield.

Sources & evidence

ORD record
ord-66add02300ba4acd86c105a7551ec1e4
Source dataset
uspto-grants-1995_03
Patent number
US05401751

Reaction notes

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