Methyl iodide → Methyl 2-(1,3-dioxaindan-5-yl)acetate

Participants

Reaction Steps

A mixture of (3,4-methylenedioxyphenyl)acetic acid (4.64 g, 25.74 mMol) in dry DMF (40 mL), cesium carbonate (9.2 g, 25.74 mMol) and methyl iodide (3.7 g, 26.0 mMol) in dry DMF (40 mL) was stirred at room temperature for 3h. At the end of this period, the reaction mixture was poured into ice water and extracted with ethyl acetate. The organic phase was washed with saturated NaHCO3, water, brine and then dried (MgSO4) and filtered. The filtrate was concentrated in vacuo to provide pure methyl (3 ,4-methylened ioxyphenyl)acetate as an oil (4.38 g).

Provenance & Evidence