HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methyl acetoacetate → HCID 20081855, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methyl acetoacetate | HCID 7757 | — |
| Reactant | 4-Fluorobenzaldehyde | HCID 68023 | — |
| Reactant | 2-Cyanoethyl 3-aminocrotonate | HCID 13671410 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | HCID 20081855 | HCID 20081855 | 94.4% |
Reaction Steps
15.4 g (0.1 mol) of 2-cyanoethyl 3-aminocrotonate, 12.4 g (0.1 mol) of p-fluorobenzaldehyde and 11.6 g of methyl acetoacetate are heated overnight under reflux in 150 ml of ethanol. After removing the solvent on a rotary evaporator, the residue is taken up in ethyl acetate, washed with water, dried and 33.8 g of crude product are obtained after removing the solvent in vacuo.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05401746 |
| Source dataset | uspto-grants-1995_03 |
| ORD ID | ord-822888c2bb73437585066775104b5b5e |
| Source note | uspto-grants-1995_03 |