Potassium Carbonate → HCID 15230481, compound

Participants

Reaction Steps

A mixture of 260 mg of 5-amino-2-(3-pyridylmethyl)-1H-isoindole-1,3-(2H)-dione, 296 mg of 1-chloro-4-iodobenzene, 131 mg of copper dust, 54 mg of 18-crown-6 (1,4,7,10,13,16-hexaoxacyclooctadecane), 569 mg of potassium carbonate and 4 ml of 1,2-dichlorobenzene was refluxed under heating for 1 hour. After finishing the reaction, the insoluble material was filtered off, and the filtrate was concentrated in vacuo. The resultant residue was chromatographed on a column of silica gel, eluting with chloroform and methanol (20:1) to give 185 mg of the titled compound.

Provenance & Evidence