Hydrochloric Acid → HCID 15230473, compound

Participants

Reaction Steps

To 12 ml of conc. hydrochloric acid were added 546 mg of stannous chloride and 352 mg of 5-[hydroxybis(4-chlorophenyl)methyl]-2-(3-pyridylmethyl)-1H-isoindole-1,3-dione, and the resultant mixture was stirred at 70° C. for 1.5 hours. After ice cooling, the reaction mixture was made alkaline with 1N aqueous sodium hydroxide and shaken with methylene chloride. The organic layer was washed with water, dried over anhydrous magnesium sulfate, and the resultant residue was chromatographed on a column of silica gel, eluting with ethyl acetate and hexane (1:1) to give 188 mg of the titled compound.

Provenance & Evidence