HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1609603Generated: November 2, 2026
3-Pyridinemethanamine → 7-(4-chlorophenoxy)-2-(3-pyridylmethyl)-1 (2H)-isoquinolinone
https://huagongshe.com/reaction/1609603
Participants
| Role | Name | HCID | Charge |
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| Reactant | 3-Pyridinemethanamine | HCID 31018 | — |
| Reactant | HCID 20082001 | HCID 20082001 | — |
| Product | 7-(4-chlorophenoxy)-2-(3-pyridylmethyl)-1 (2H)-isoquinolinone | HCID 15230478 | 72.9% |
Reaction Steps
A mixture of 100 mg of 7-(4-chlorophenoxy)isocoumarin and 377 mg of 3-aminomethylpyridine was heated at 180° C. without solvent under stirring for 5 hours. After finishing the reaction, the mixture was chromatographed on a column of silica gel, eluting with ethyl acetate to give 97 mg of the titled compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US05401756 |
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| Source dataset | uspto-grants-1995_03 |
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| ORD ID | ord-d13622414e284897b89799995bfbbd53 |
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| Source note | uspto-grants-1995_03 |
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