L-Isoleucine → HCID 86748590, compound
Reaction equation
[NH2:1][C@H:2]([C:7]([OH:9])=[O:8])[C@H:3]([CH2:5][CH3:6])[CH3:4].C[O-].[Na+].O.O.C([O-])(=O)C.[Zn+2:19].C([O-])(=O)C>CO>[Zn:19].[NH2:1][C@H:2]([C:7]([OH:9])=[O:8])[C@H:3]([CH2:5][CH3:6])[CH3:4]Participants
5
Reactant 3
Product 1
Reagents, catalysts & solvents 1
Procedure
L-isoleucine (2.00 g, 15.3 mmol) was added to an MeOH solution of NaOMe (prepared with Na: 0.35 g, MeOH: 50 ml) at 0° C. and stirred. An MeOH solution (30 ml) of zinc acetate dihydrate (1.67 g) was then slowly dropwise added thereto at room temperature. After stirring for hours at the same temperature, the solution was concentrated to half its original volume, followed by the addition of an equal volume of water. The precipitated crystal was recovered by filtration, air dried, and then dried under a reduced pressure (5 mmHg, 80° C.).
Workup
- customat room temperature
- stirringAfter stirring for hours at the same temperature
- concentrationthe solution was concentrated to half its original volume
- additionfollowed by the addition of an equal volume of water
- filtrationThe precipitated crystal was recovered by filtration, air
- customdried
- customdried under a reduced pressure (5 mmHg, 80° C.)
Sources & evidence
- ORD record
- ord-9248562ba6654c958792382e5b07d7bf
- Source dataset
- uspto-grants-1995_03
- Patent number
- US05401770
Reaction notes
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