L-Leucine → HCID 86748591, compound

HRID 1609613Notes

Reaction equation

HRID 1609613 reaction equation
[NH2:1][C@H:2]([C:7]([OH:9])=[O:8])[CH2:3][CH:4]([CH3:6])[CH3:5].C[O-].[Na+].O.O.C([O-])(=O)C.[Zn+2:19].C([O-])(=O)C>CO>[Zn:19].[NH2:1][C@H:2]([C:7]([OH:9])=[O:8])[CH2:3][CH:4]([CH3:6])[CH3:5]

Participants

5

Reactant 3

HCID 6106L-LeucineHCID 2724192Zinc acetate (USP)HCID 10942334Sodium Methoxide

Product 1

HCID 86748591HCID 86748591, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent2×

Procedure

L-Leucine (2.00 g, 15.3 mmol) was added to an MeOH solution of NaOMe (prepared with Na: 0.36 g, MeOH: 50 ml) at 0° C. and stirred. An MeOH solution (30 ml) of zinc acetate dihydrate (1.67 g) was then slowly dropwise added thereto at room temperature. After stirring for 2 hours at that same temperature, the solution was concentrated to half its original volume, followed by the addition of an equal volume of water. The precipitated crystal was recovered by filtration, air dried, and then dried under a reduced pressure (5 mmHg, 80° C.).

Workup

  1. customat room temperature
  2. stirringAfter stirring for 2 hours at that same temperature
  3. concentrationthe solution was concentrated to half its original volume
  4. additionfollowed by the addition of an equal volume of water
  5. filtrationThe precipitated crystal was recovered by filtration, air
  6. customdried
  7. customdried under a reduced pressure (5 mmHg, 80° C.)

Sources & evidence

ORD record
ord-b1df07a5a7f34b1da1d0ffdbf412f80a
Source dataset
uspto-grants-1995_03
Patent number
US05401770

Reaction notes

Loading…