反应详情

温度

100 °C

A mixture of 5-benzyloxy-2-vinyl-4-pyridone (3.12 g) , 50% aqueous solution of dimethylamine (15 ml) and ethanol (35 ml) was heated at 100° C. in a sealed tube for 8 hours. The resulting mixture was cooled and concentrated under reduced pressure to dryness. The residue was triturated with a mixture of ethyl acetate and diisopropyl ether to give 5-benzyloxy-2-[2-(N,N-dimethylamino )ethyl]-4-pyridone (3.45 g) as a powder.

1. temperatureThe resulting mixture was cooled
2. concentrationconcentrated under reduced pressure to dryness
3. customThe residue was triturated with a mixture of ethyl acetate and diisopropyl ether