Pyrrolidine → 4-Oxazolidinecarboxaldehyde, 3-acetyl-2,2-dimethyl-5-[4-(methylthio)phenyl]-, (4S-cis)-

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Reaction Steps

Pyrrolidine (9.6 mg; 0.065 mmol) was added at 25° C. to a solution of compound 4 (see example 3) (100 mg, 0.34 mmol) in toluene (2 ml) kept under magnetic stirring and under nitrogen. At the end of the addition the mixture was kept at 25° C. under stirring for 14 hours. The reaction mixture was then poured into 10% NaHCO3 ; after separation of the phases, the aqueous phase was extracted with CH2Cl2. The combined organic phases were dried over sodium sulphate and evaporated to dryness under vacuum.

Provenance & Evidence