HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → HCID 18651235, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Toluene | HCID 1140 | — |
| Reactant | (1S,2S)-(+)-2-Amino-1-[4-(methylthio)phenyl]-1,3-propanediol | HCID 688165 | — |
| Solvent | Acetone | HCID 180 | — |
| Product | HCID 18651235 | HCID 18651235 | — |
Reaction Steps
A stirred mixture of enantiomerically pure (+)-thiomicamine (100 g; 0.469 mol), toluene (920 ml) and acetone (100 ml) was heated at reflux for 18 hours beneath a Dean Stark trap: a mixture of toluene, water and acetone (11 g) was collected. The solvent (200 ml) was distilled at ambient pressure and then under vacuum (internal temperature 80° C.) to give compound 7 (118.6 g) as residue.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05401852 |
| Source dataset | uspto-grants-1995_03 |
| ORD ID | ord-ad5b5b69c1424b6f87f7a794ac4e9f08 |
| Source note | uspto-grants-1995_03 |