HCID 22866671, compound → HCID 22866669, compound

Participants

Reaction Steps

4-{4-[(2-benzyloxy-1,2-dioxoethyl)amino]-2,6-dichlorophenoxy}-2-isopropylphenyl 3,7,12(3α,5β,7α, 12α)-trihydroxycholan-24-oate (260 rag) and 26 mg of 10% palladium on carbon in 50 ml ethanol are treated with hydrogen on a Parr shaker. Catalyst is removed by filtering through Celite and the filtrate is stripped to give 4-{2,6-dichloro-4-[(2-hydroxy-1,2-dioxoethyl) amino]phenoxy}-2-isopropylphenyl 3,7, 12(3α,5β,7α, 12α)-trihydroxycholan-24-oate, as an amorphane monohydrate, m.p. 180°-92° (dec.).

Provenance & Evidence