HCID 69352738, compound → HCID 69351642, compound

Participants

Reaction Steps

A mixture of 1-benzyl-(3S)-3-(4-nitrophenoxy)piperidine (6.5 g) and 1.2 g of 10% Pd/C in methanol (30 mL) was subjected to hydrogenation (50 psi). When the reaction was completed, the reaction mixture was filtered. The filtrate was concentrated in vacuo, giving a yellow solid. Recrystallization in CH2Cl2/hexane afforded (3S)-3-(4-aminophenoxy)piperidine (3.5 g, 88% yield) as a white solid.

Provenance & Evidence